Why did Jennifer Aniston turned down main role in 2001's Serendipity?

Jennifer Aniston turned down main role in 2001's Serendipity. Director Peter Chelsom told Insider, "I distinctly remember Jennifer Aniston coming in to meet us. By then, she was rocketing to fame on the hit show Friends".

"I remember when she came in, she said, 'I do a romantic comedy once a week,' her being on Friends at the time.

"So, she clearly had other things on her plate and it was her decision not to do it.

"She had come to meet with me in good faith without an offer, but we definitely would have made her an offer if she wanted to make it."

Then Kate Beckinsale took the role for Serendipity, along with John Cusack.